What is Matrixyl 3000 & How Can it Give You Younger-Looking Skin?

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Do some research into the best anti-aging skincare ingredients and you’ll find that peptides are recommended by just about everyone. What makes things a little confusing is the fact that there are so many different peptides out there – which one do you choose?

Turns out, the more peptides that you use, the better. This is where Matrixyl 3000 really stands out. It’s classed as a peptide but it’s actually made up of two peptides that have been combined together. Let’s take a closer look at this groundbreaking ingredient…

What is Matrixyl 3000?

Matrixyl 3000 is a synthetic peptide. It’s created by combining palmitoyl oligopeptide and palmitoyl tetrapeptide-7 (also known as Pal-GQPR) – two peptides that, when used individually, are already very powerful. Sederma, who manufactures Matrixyl 3000, recognized how these two peptides work synergistically together, leading them to create Matrixyl 3000.

A Closer Look at Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, and Amino Acids

Amino acids

Before we delve into the benefits of Matrixyl 3000, let’s quickly take a look at the two peptides that make up its composition. Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide-7 are actually very similar. The main difference between these peptides is that the former is made up of three amino acids, while the latter consists of four. But what does this actually mean?

To put it simply, amino acids are the building blocks that your skin uses to build proteins, such as collagen and elastin. All peptides are made up of amino acid chains, some longer than others. When peptides contain more than 50 amino acids, they’re referred to as polypeptides.

What Does Matrixyl 3000 Do for the Skin?

Although the different peptides out there are relatively similar, they all differ when it comes to the amino acids that make them up. This means that they each have their own effect, enabling them to tackle the unique needs of every skin type. Let’s take a look at what you can expect to see after regularly using skincare products containing Matrixyl 3000:

Minimizes Fine Lines and Dynamic Wrinkles

The ability to reduce fine lines and wrinkles is something that you’d expect from any anti-aging ingredient, and Matrixyl 3000 doesn’t disappoint. In fact, there have been numerous studies carried out on the peptide’s anti-aging effects, and the results are always impressive.

Research shows that two months of using Matrixyl 3000 will give you a 15% reduction in wrinkle depth and an 18% reduction in wrinkle volume, along with a 37% reduction in wrinkle density [1].

These effects are all thanks to how Matrixyl 3000 can stimulate collagen production. The more collagen you have in your skin, the firmer and smoother your skin will be. Since natural collagen production declines with age, as well as with increased sun exposure, boosting your skin’s levels of this protein is what will bring back your skin’s youthful appearance.

Woman Looking At Wrinkles Touching Face Standing In Bathroom Indoor

Increases Natural Production of Hyaluronic Acid

Hyaluronic acid is another substance that’s naturally produced by the body. It keeps the skin and joints lubricated and hydrated. Again, levels of this humectant decline with age. This not only means that the skin takes on a drier and duller appearance, but it also affects how full and plump your skin looks. As a result, wrinkles and expression lines become so much more noticeable.

There are numerous skincare products out there that contain the humectant, as well as its salt form derivative, sodium hyaluronate. However, nothing quite beats the quality of the hyaluronic acid that your skin produces itself. There aren’t many topical ingredients out there capable of increasing natural hyaluronic acid production, and therefore skin moisture levels, but Matrixyl 3000 is able to do the job [2], and it does it well.

Improves Skin Texture

If you’ve been noticing that the surface of your skin looks rough and uneven, then Matrixyl 3000 can help. The way in which the peptide increases both collagen and hyaluronic acid production helps with firmness, giving your skin a smooth and soft finish. Use the peptide regularly and you’ll notice a reduction in skin roughness of up to 14%.

Brightens Skin Tone

If brighter skin is your aim, then Matrixyl 3000 would be very beneficial. Unlike many of the other skin brightening treatments available, this peptide doesn’t actually affect melanin production in the skin. Instead, its brightening effects are due to how it encourages the skin to produce more hyaluronic acid. With the humectant giving the skin a plumper and fuller appearance, the skin then takes on a brighter and more radiant glow.

Adding Matrixyl 3000 to Your Skincare Routine

Middle age woman holding cotton pads

Thanks to the increasing number of studies available confirming how useful Matrixyl 3000 can be in the fight against wrinkles and facial aging, you’ll now find the peptide in a wide range of products.

The best way to use the peptide would be in a serum. Since a serum is so much more lightweight than a cream, the ingredients in its formula, including its peptides, are able to penetrate deeper into the skin, making them more effective.

As mentioned earlier, the more peptides you use, the better. So, look for a serum that combines Matrixyl 3000 with other peptides. Palmitoyl tripeptide-1, also known as Pal-GHK, would be a good choice. Acetyl hexapeptide-8 is another one to look out for – this peptide inhibits the neurotransmitters that activate movement in the facial muscles, helping to keep your face line-free.

Vitamin C is another ingredient that pairs well with the peptide. Just like Matrixyl 3000, vitamin C helps to tackle wrinkles while brightening the skin.

One formula worth considering is The Ordinary Matrixyl 10% + HA. In addition to Matrixyl 3000, it also makes use of Matrixyl Synthe’6, a peptide that helps to activate skin cells to keep them functioning efficiently. This anti-aging blend also contains multiple humectants to maintain skin moisture levels, including glycerin and sodium hyaluronate.

Does Matrixyl 3000 Have Any Side Effects?

You’ll be happy to hear that, so far at least, Matrixyl 3000 doesn’t come with any known side effects. However, keep in mind that this peptide is a relatively new ingredient, meaning that research on its long-term effects is still limited.


Young woman cleaning up her face

Is Matrixyl 3000 better than retinol?

Matrixyl 3000 and retinol have very similar effects. However, Matrixyl 3000 doesn’t seem to cause the side effects that retinol is known for triggering. That said, there’s no reason why you can’t use both ingredients together in your skincare routine.

How long does it take for Matrixyl 3000 to work?

It will take several weeks before you notice a difference in your skin after using Matrixyl 3000. However, you’ll need to wait for a couple of months before the major improvements become visible.

Does Matrixyl 3000 cause sagging skin?

No, Matrixyl 3000 doesn’t cause sagging skin. In fact, it’s able to help reduce and prevent sagging and wrinkles, which is why it’s such a popular skincare ingredient.


If your anti-aging skincare routine doesn’t yet contain Matrixyl 3000, it’s time to add this peptide in. You’ve probably tried many ingredients in the past that just don’t seem to have much of an effect on your wrinkles, but this is where Matrixyl 3000 really shines. This revolutionary peptide not only increases collagen levels but also amps up skin hydration – not only will your wrinkles soon be a thing of the past, but your overall complexion will look so much healthier too.


[1] http://www.smartskincare.com/treatments/topical/Matrixyl3000report.pdf
[2] https://www.mdpi.com/2079-9284/4/2/16/pdf

Avatar for Megan Foley

Megan has been a freelance writer and editor since 2016. In that time, she’s penned a diverse collection of articles for online publication, with a focus on skincare and beauty. From in-depth product reviews to concise marketing content, Megan is passionate about developing content that informs, entertains, and inspires.