Musely Review & Face Rx: Are These Skincare Products Worth Buying?

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Although telemedicine isn’t a new concept, the pandemic has exposed it to the masses, allowing people to have their health and skin conditions treated from the comfort of their own homes. In the dermatology field, telemedicine has meant that more people now have access to specialized prescription products. They’re able to receive personalized advice from some of the best dermatologists in the country, enabling them to finally eradicate the skin concerns that have been plaguing them for years.

With telemedicine growing in popularity, you’ll now have your pick of skincare companies that offer this service. One such brand is Musely. Their personalized prescription skincare has been in the limelight lately, and while some rave about their products, others aren’t quite so thrilled. We decided to take a closer look at the brand and its skincare treatments – our Musely Face RX review shares what we discovered.

skin regeneration set

Who is Musely?

Musely was created back in 2012 by a team of board-certified medical doctors and dermatologists. They claim to offer the only FDA-approved treatment for anti-aging concerns, which, as you can imagine, has earned them quite the following.

What sets Musely apart from other skincare brands is the fact that they operate via an online dermatology clinic. Rather than simply ordering the products that they want, customers first undergo a dermatologist evaluation, after which they’ll be prescribed their personalized skincare. This service is known as Musely Face RX.

How Exactly Does Musely Face RX Work?

Each treatment begins with a skin evaluation. This is where you record your skincare history and goals. This information will then be reviewed by a qualified medical professional, after which your treatment plan will be created. The same skincare professionals will then be on-hand through the brand’s app to consult with you for the next 60 days.


Musely Skin Care Treatments

Musely offers multiple topical creams and treatments. Your online dermatologist visit will determine which ones the brand sends to you, along with how that specific formula is customized for your skin. Let’s take a look at some of the products that the Face RX treatment includes:

The 4-Piece Musely Skin Regeneration Set

The four products in the Musely Face RX Skin Regeneration Package offer a complete anti-aging routine. When you first sign up with Musely, you’ll need to purchase the entire Skin Regeneration Set. However, when it comes to refills, you can pick and choose the products that worked the best for you.

Here’s what you’ll find in the Skin Set:

The Night Cream

Musely The Night cream

The Musely Face RX Skin Set includes the night cream, a popular product from the brand that can’t be purchased individually. Tretinoin is the active ingredient in this formula. It’s believed to be the most potent of all of the retinoids available [1], making it one of the most effective ingredients for treating fine lines, wrinkles, and aging skin.

Unfortunately, that potency comes with side effects, which is why Musely produces this cream in three different strengths. Whichever strength you end up with, the hyaluronic acid in this formula is great for hydrating skin, which is exactly what your skin needs to function optimally at night.

The Day Cream

Musely The Day cream

The main benefit of the Musely Face RX Day Cream is that it offers a mineral form of SPF 50. It also contains a few humectants, including hyaluronic acid, making it a good formula for keeping the skin hydrated.

However, the rest of its ingredient list looks a little lacking. Granted, the main purpose of a day cream is to protect the skin from environmental damage, but there’s a lot more to this than simply blocking UV rays. It’s a shame that this formula doesn’t also contain a few vitamins and antioxidants to defend against other daytime skin stressors, such as pollution.

The Cleanser

Musely The Cleanser

Although they may have missed the mark when it comes to the antioxidant content of their day moisturizer, Musely has more than made up for this with their cleanser. It contains a long list of carefully selected fruit and herb extracts. When combined with cleansing ingredients, this formula has the potential to really improve skin tone and skin texture.


Musely eNurse

eNurse is a special feature on the Musely app that has been designed to guide you through your Musely Face RX journey. You’ll be able to check in with your assigned healthcare provider to discuss any questions or concerns that you may have. You’ll also be able to personalize your treatment and track your progress, making it useful in determining whether or not your treatment is working for you.


The Musely Spot Cream

Musely The Spot Cream

If you’re dealing with stubborn dark spots on your face, then chances are that Musely will send you their dark spot correcting cream. This spot cream is packed with some truly potent skin brightening ingredients, including hydroquinone, azelaic acid, and kojic acid. These ingredients target pigmented skin cells, which are what lead to the appearance of dark spots. They break up melanin clusters to fade dark spots and bring back an even skin tone.

Since hydroquinone can cause mild skin irritation on sensitive skin, this spot cream is also available without the ingredient. Again, the dosage and formula of this product will vary based on your skin’s needs.


The Spot Peel

Musely The Spot Peel

Another product designed to target dark spots, the Musely Face RX Spot Peel is a one-time treatment designed to be used every six months. While it contains some of the same active ingredients as the spot cream, it has also been formulated with tretinoin, vitamin C, and arbutin. Not only do each of those ingredients brighten skin, but they’ll also help to speed up skin cell turnover to fade sun spots and acne scars.

This formula is offered in two strengths. The first gives your skin an initial boost, while the second is for skin upkeep.


The Private Cream

Musely The Private Cream

Many experience dark spots in their private areas, and this is what the Musely Face RX Private Cream is designed to treat. Since these areas of the body are also pretty sensitive, the cream not only contains the brand’s signature brightening active ingredients, but you’ll also find tranexamic acid in this blend. This powerful anti-inflammatory prevents excess melanin production while soothing and calming the skin.


The Neck Cream

Musely The Neck Cream

Designed to be used on the neck and chest, the Musely Face RX Neck Cream is made with similar ingredients to the brand’s other brightening products. Hyaluronic acid hydrates skin cells and keeps fine lines at bay, while hydroquinone targets pigment to brighten dull skin, and tretinoin increases collagen production.

There are two formulas available. The first is aimed at smoothing wrinkles, while the second focuses on treating damage caused by sun exposure, meaning less discolored skin.


The Cleanser & Day Cream Bundle

Musely The Cleanser & Day Cream Bundle

This skincare set is the only over-the-counter product sold by Musely. It contains the SPF day moisturizer and the cleanser, both of which we’ve already covered. While having to purchase both if you only need one is a little frustrating, this bundle does come in at a price that offers good value for money.


Do Musely Products Have Any Side Effects?

Now onto the part that causes us the most concern – the side effects. We read through several Musely Face RX reviews, and while some were able to use this product without their skin reacting, others had the opposite experience.

Musely themselves make it clear that side effects are to be expected. After all, these are powerful, prescription-strength products. According to Musely reviews, as well as the official Musely website, some of the most common side effects are:

  • Redness
  • Dryness
  • Peeling
  • Itching
  • Irritation
Woman cleaning her face

What Happens If You Experience Skin Irritation After Using Musely’s Products?

If you do happen to experience side effects from your Face RX creams or treatments, Musely’s advice is to decrease the use of that product and to keep your skin moisturized. However, you’ll need to also update your eNurse app to reflect these side effects. If you don’t, or if you decide to stop using the products altogether, you won’t be able to make use of the brand’s 60 Day Results Guarantee, which enables you to be refunded for the cost of your treatment. It’s definitely concerning that, even if you experience severe side effects from these products, you’ll need to continue using them for the remainder of your 60 days if you want your money back.


happy middle aged woman smiling at the camera

Is Musely legit?

Yes, Musely is a legit company consisting of a team of dermatology professionals. In addition to treating your skin, they’re also able to offer personal health advice.

Is Musely FDA approved?

Yes, Musely Face RX is the only FDA-approved anti-aging line available. This is how the brand is able to claim that they offer the best skin care treatment for fine lines, dark spots, and other aging-related concerns.

How much does Musely cost?

Musely varies in price depending on the treatment plan you pick.

How long does it take for Musely to work?

Musely spot cream reviews show that Musely Face RX products start to work in just a couple of weeks. However, it will take about two months before changes are implemented deeper in the skin.

Are Musely Skincare Products Worth Buying?

Compared to a real-life dermatologist visit, along with the price of the prescription products recommended to you, Musely products do seem to offer good value. However, when it comes to your skin, it’s not all about the money…

The way in which the brand deals with side effects is worrying. Reviews show that many customers had trouble obtaining their guaranteed refunds after experiencing skin problems, which would make us a little hesitant about investing in these products, especially with many of the side effects being severe.

If you would prefer to go with an anti-aging product that doesn’t come with the risk of serious side effects, we would recommend XYZ Smart Collagen. Several studies have found this product to be extremely effective at reducing fine lines and tightening wrinkled, sagging skin. Find out more about it here, so that you can then make the very best decision for your skin.



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Avatar for Megan Foley

Megan has been a freelance writer and editor since 2016. In that time, she’s penned a diverse collection of articles for online publication, with a focus on skincare and beauty. From in-depth product reviews to concise marketing content, Megan is passionate about developing content that informs, entertains, and inspires.