Complete Stemuderm Review: Cost, Ingredients, Complaints & Free Trial

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The skincare world is overwhelmed with products claiming to combat wrinkles, fill in fine lines, and make your face appear younger and more vibrant. In fact, we’ve compiled a list of all of the best of them.

Our top choice is the complete anti-aging regime from [promo-showProductName].

Our team found this line’s unique hydrating, all-natural antioxidant blend resulted in fewer fine lines, better skin elasticity, a brighter complexion, and impressively well-hydrated skin.

We can’t recommend any of the Renew collection products enough! Check out all [promo-showProductName] has to offer by clicking here.

However, today we’re excited to share with you Stemuderm anti-wrinkle treatment cream. Keep reading for our full Stemuderm review.

How Does It Work?

Stemuderm is a super concentrated serum that combines stem cells, peptides, and moisturizes to smooth skin and make it more radiant.

Its power comes from attention to all signs of aging, unlike other skin care products that focus on one aspect at a time.

The primary focus of Stemuderm is decreasing the appearance of fine lines and wrinkles – two telltale signs your skin is getting older.

It does this by relaxing the contracted muscles under your skin to smooth out wrinkles and prevent new ones from forming. Stemuderm also includes ingredients to plump your skin which aids in hiding hard to treat fine lines.

Where other anti-wrinkle creams fail to focus is the skin’s hydration levels. Dry skin shows age spots and wrinkles more than healthy, moisturized skin.

Stemuderm includes multiple moisturizing ingredients to keep your complexion smooth and glowing.

By treating skin from the inside out, Stemuderm encourages a healthier, tighter, and more youthful face.


Who Makes It?

Stemuderm anti-wrinkle cream is manufactured in the USA by a company called Solvaderm. This company brings together dermatology professionals across specialties to create the most effective formulas possible.

The variety of perspectives included guarantees that the ingredients are safe and optimized for maximum effectiveness.

young pretty girl clear skin

What’s In It?

Particularly where skincare is concerned, Stemuderm has a short list of active ingredients. They fall primarily into three categories: peptides, stem cells, and moisturizers.

Below we dive deeper into what’s working together in this anti-wrinkle cream.


Peptides limit muscle contractions beneath the skin. Contractions are the result of repetitive facial movements, such as speaking or smiling. This chronic use shows up as fine lines and wrinkles.

Peptides in Stemuderm swoop in to relax your face muscles and consequently reduce the appearance of lines.

Stemuderm includes the following peptides:

  • Acetyl Hexapeptide-8 is a unique ingredient often referred to as “Botox in a Jar.” It decreases the appearance of fine lines and wrinkles and prevents new ones from forming. To get technical, Acetyl Hexapeptide-8 is a polypeptide composed of amino acids. Amino acids encourage productions of essential nutrients and healthy skin functions.
  • Dipeptide Diaminobutyroyl Benxylamide Diacetate, often shortened to SYN-AKE, is another peptide that relaxes facial muscles and reduces fine lines. This one mimics the function of snake venom and specifically targets crow’s feet and laugh lines – two aging signs that appear early and are often hard to make disappear.
  • Matrixyl 3000 is a mixture of peptides that counteracts signs of aging. This combo, in particular, has been shown to diminish wrinkles by 45% on its own with regular use. Combined with the other ingredients in the Stemuderm cream, Matrixyl 3000 becomes even more unstoppable at making your skin look younger.


Stem Cells

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As your skin ages, it loses elasticity. Without the ability to bounce back into place, wrinkles become more apparent, and your skin seems to sag or look puffy.

Stem cells in Stemuderm work to revive your skin’s natural elasticity and even out your skin tone.

  • Malus Domestica is a plant-based stem cell. It comes from a rare, Swiss apple and, as a result, provides antioxidants and anti-inflammatory boosts to your skin. Malus Domestica protects, repairs, and heals your skin while simultaneously diminishing imperfections. This combination leaves healthier, more even, more youthful skin in its wake.


Many anti-aging products on the market focus all of their efforts on wrinkle reduction. While this element is essential, it misses the fact that skin care requires a comprehensive approach.

Adequate moisture is vital for keeping skin healthy and vibrant – two characteristics that also help skin appear younger!

The three primary moisturizers in Stemuderm are:

  • Hyaluronic Acid is one of the most effective, potent moisturizers around today. It occurs naturally in the skin but often requires supplementation as we age. A unique benefit of hyaluronic acid is its ability to plump skin. Plumping reduces the appearance of fine lines and creates the illusion of more even complexion. This is one of the key ingredients in adding to the overall youthfulness of your face.
  • Apricot kernel oil is a natural compound that both nourishes and softens skin. It contains a variety of moisturizing elements including Vitamin E, linoleum acid, and Leicester acid. Think of apricot kernel oils as an additional toner working to prepare your face for the rest of the ingredients in the Stemuderm cream to work.
  • Squalane is a moisturizer extracted from olive oil. Its primary function is to lock in moisture and keep your skin hydrated. Specifically, it works by reducing the ability of your skin to lose moisture, therefore keeping it soft and looking great.

How Do You Use It?

Using Stemuderm cream is an effortless addition to your regular skincare routine.

Every morning and evening, wash and tone your face like normal and then use your fingers to apply the cream to your face, neck, and décolleté.

It’s recommended that you massage the cream into your skin using a circular motion, paying particular attention to problem areas like crow’s feet, sagging neck skin, or puffy areas underneath your eyes.

Suvoderm Anti  Wrinkle Night Cream Product Review

Because Stemuderm is extremely concentrated, the manufacturers recommend easing your way into use.

Begin applying the cream every other day for the first week, then once daily for the second, and then begin using it twice daily during the third week of use if you’ve had no reactions or problems.


Are There Side Effects?

No serious side effects to Stemuderm anti-wrinkle cream exist. However, some reviews report irritation or burning feelings.

Others shared complaints of itchiness, increased hair growth, darkening of face spots, and dry skin.

If you have sensitive skin or experience any side effects, be sure you are following the recommended Stemuderm transition process.

Irritations are most likely the result of your skin adjusting to the intense formula and will eventually subside.

Is It As Good As It Claims?

One of the downsides to Stemuderm is that all of the reviews and before and after pictures are shared on the official website or through affiliate sellers. Which makes you question, does it work?

Reviews are generally positive with people experiencing more even skin and a reduction of fine lines and wrinkles. Most negative customer reviews result from individuals who experience irritation using Stemuderm.

The official Stemuderm website is the best place to read real reviews as affiliates receive compensation for cream sold through their links.

stemuderm review

With the high-end, mostly natural ingredients that are quality controlled and scientifically researched, we feel confident recommending it in our Stemuderm review. Overall, it is a decent, mid-range anti-wrinkle product.

To see a full list of our favorite anti-aging products, including Kremotex, check out our comprehensive best anti wrinkle cream article.

How Does Stemuderm Compare to Other Products? 

Now we have seen what Stemuderm has to offer, how does it compare to other anti-wrinkle creams in the market? 

For the purposes of this comparison, we will compare it to three other similar and highly-rated anti-wrinkle solutions in the market: LifeCell and DermaWand. Particularly, we will focus our attention on their results and known side effects.


This anti-aging product is not like the typical cream—it’s a wandlike device that uses an emitted radio frequency to smooth over your skin, eliminate wrinkles, rejuvenate your skin cells, and reduce puffiness. To use it, you have to swipe the toning tip of the wand repeatedly across your face twice a day. 

Of course, you’re basically zapping your skin with radiation. So, while DermaWand doesn’t hurt much, depending on the settings, you might experience some pain in your face. Furthermore, it may cause adverse reactions on some people’s skin, causing redness, irritation, and even a burn or two. 

Is it effective? Well, 83% of its users report their faces being way younger within the first four weeks, though the effects are quite noticeable in the first few days. Compare this with the 89%  for Stemuderm, especially regarding wrinkle depth. 

However, this is where its comparative disadvantage to cream–based solutions like Stemuderm comes in. Dermawand and treatments like it are not particularly long-lasting in their effects, especially on wrinkles. 

Your skin may start reverting to its prior state within a few weeks of stopping. Furthermore, you have to swipe with DermaWand for 30 minutes (15 minutes apiece) daily, which will already be too long for most people. 


Unlike DermaWand, and much like Stemuderm, LifeCell is a cream-based solution. However, while Stemurderm and Dermawand are made for a range of skin aging-related skin issues, LifeCell specifically targets skin wrinkles (though it’s not necessarily ineffective for other issues.) 

In any case, Lifecell employs several great measures to do its job, especially light-reflecting microtechnology. What the product does includes stimulating of collagen production, deleting wrinkle-causing free radicals, improving blood circulation, and aiding skin regeneration.

Due to all these many things it does, the effects are generally very long-lasting. Moreover, you will begin to see its effects almost immediately after applying it.

However, LifeCell has some significant downsides. Other than the occasional case of irritation, it can also cause inflammation and even skin breakouts in some patients. 

Furthermore, it is comparatively less affordable than Stemuderm and many other very reputable products, it has many bad reviews, and very few studies on its efficacy exist at the moment.

Stemuderm Review Final Toughts – Should You Purchase Stemuderm?

You can buy Stemuderm through their official website or using affiliate links. It is not available through Amazon or Walmart.

Coupons are not frequently available, making Stemuderm a slightly high-cost anti-aging product. The price of one month’s supply is $79.99.

While Stemuderm is an excellent option, if you’re looking for a complete skincare regime, we recommend checking out [promo-showProductNameAffLink].

Their people- and planet-safe all-natural line of anti-aging products offers everything you need to get a flawless, glowing, youthful complexion.

Powerful antioxidants work to combat free radicals, while a moisture-rich formula rebuilds your skin’s natural defenses and elasticity.

Our team loved the optional add-ins for the regime and saw real results. They even offer subscription plans on any product—or products—for a 10% discount!

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Avatar for Megan Foley

Megan has been a freelance writer and editor since 2016. In that time, she’s penned a diverse collection of articles for online publication, with a focus on skincare and beauty. From in-depth product reviews to concise marketing content, Megan is passionate about developing content that informs, entertains, and inspires.