Glutathione Suppositories: How Do They Work & Are They Worth Taking?

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Glutathione is an antioxidant that we’ve covered in detail – we’ve discussed glutathione skincare products, oral supplements, and injections.

However, today we’re going to talk about a less common, but very effective, way of increasing your body’s glutathione levels; glutathione suppositories. Keep reading to find out what they are, how they work, and if the results make them worth taking.

What Are Glutathione Suppositories, How Do Suppository Pills Work, and What Are Their Benefits?

Glutathione suppositories

A glutathione suppository is a dose of glutathione that’s inserted into the body, usually via the rectum.

It’s made up of a base ingredient, such as cocoa butter, which wraps around glutathione.

As the base ingredient heats up, it melts, releasing the glutathione into the body at a controlled rate, after which it’ll make its way into the bloodstream.

Some suppositories will contain pure glutathione, while others will combine the antioxidant with other vitamins.

We would recommend choosing a multivitamin blend that includes vitamin C, as this enhances the effects of glutathione.

Let’s take a look at some of the benefits provided by a glutathione suppository:

Skin Lightening & Whitening Effects

Glutathione supplementation boosts skin health in many ways, while also having a whitening effect. It counters excess melanin production, therefore evening out your skin tone and fading age spots.

Glutathione can be found in many skin lightening creams as well. Read our guide and find out what are the most effective skin whitening creams.

Antioxidants Fight Free Radicals & Repair Damage in the Skin & Body

Woman with inflamed skin

Being an antioxidant means that glutathione is able to prevent free radical damage.

This damage caused by free radicals is responsible for everything from accelerated aging to several diseases, making glutathione a great way to support various functions in your body, and therefore your overall health.

Anti-Inflammatory Properties Support Gut Health, Especially When Combined With a Probiotic

In addition to being an antioxidant, glutathione is also a powerful anti-inflammatory. This not only supports gut health but also benefits all of the cells in your body.

Liver Detoxification & Immune Support

Glutathione encourages the removal of toxins, which then enhances the rate at which the body produces its own glutathione. This is something that usually declines with age, as well as due to sun exposure, environmental pollutants, stress, and free radical damage.

Additionally, rectal suppositories containing glutathione strengthen the immune system.

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Glutathione Suppository vs Oral Medication vs Injections: Which is Best for Maximum Absorption?

So, why would you subject yourself to a glutathione suppository if you could take oral supplements or glutathione injections instead?

It’s simple – unlike oral supplementation, rectal suppositories are delivered directly into the bloodstream. They don’t have to deal with your digestive system, allowing your organs, including your skin, to benefit even more from all that the ingredient offers.

Injections work in the same way. However, they’re expensive – suppositories are significantly cheaper than glutathione injections, making them ideal for those on a budget.

Before and After Results & Reviews

Glutathione suppositories aren’t anything new. In fact, they’re a common go-to treatment in Asia for those looking to lighten hyperpigmentation and reduce wrinkles. As a result, there are hundreds, if not thousands, of before and after photos and reviews out there.

We scoured them all and were very impressed. It takes a few weeks for results to become noticeable, but, after this, they continue to improve for several months.

Not only do dark spots fade away, but due to the DNA repair abilities of glutathione, overall skin health is boosted, which gives people a gorgeous glow.

RELATED: Glutathione for Skin

Do Suppositories Burn? The Side Effects of Taking a Glutathione Suppository

It’s true – suppositories can sometimes initially burn, but this is a side effect that subsides very quickly. Other than that, there aren’t any major side effects related to glutathione suppositories, so long as the suppository, you’re using only contains natural ingredients.

If you’ve experienced any problems after using suppositories, seek advice from your doctor and ask them any further questions you may have.

Pretty brunette in white top


Q: Are glutathione suppositories effective?

Yes, so long as they contain active ingredients in a strong enough dose, glutathione suppositories are very effective.

Q: What are glutathione suppositories used for?

They’re used for a number of different purposes, from skin whitening to removing toxins from the liver to protecting the kidneys.

Q: Can you take glutathione rectally?

Yes, glutathione can be taken rectally.

Q: What happens if you take too much glutathione?

Too much glutathione can lead to lowered zinc levels in the body, which can cause health issues to arise.

Q: How long does glutathione take to whiten?

It takes about 2-3 weeks for glutathione’s whitening effects to become visible

Q: How quickly does the glutathione capsule work?

Glutathione capsules take 3-4 weeks to work.

Q: How long does the glutathione effect last?

Glutathione stays in the body for 2-3 months, so this is how long its effects will last if you don’t keep it topped up.

Q: Why you should not take glutathione?

If you’re taking other medications, then speak to your doctor to make sure that glutathione won’t react with any of them. Other than that (with the exception of pregnant women), it’s safe for everyone.

Are you struggling with dark skin after pregnancy? Read our article and learn how to lighten skin after pregnancy.

Q: What is the most absorbable form of glutathione?

Glutathione injections and IV drips are the most absorbable form of glutathione.

Q: Can I take Vitamin C while taking glutathione? What about other vitamins or a multivitamin?

Yes, it’s safe to take vitamin C and other vitamins while taking glutathione. In fact, this could actually enhance the effects of glutathione.

Q: Can glutathione cause miscarriage?

It’s not yet known if glutathione is safe to be taken during pregnancy. However, low glutathione levels in the body have been linked to miscarriages and pregnancy complications [1].

Pregnant woman day dreaming

Q: When is the best time to take glutathione – is it better to take glutathione in the morning or at night?

It’s best to take glutathione at night before bed.

Q: Is glutathione bad for the heart?

No, glutathione is not bad for the heart. Instead, it’s very beneficial and can help to prevent heart disease.

Q: How to make a glutathione suppository at home? What ingredients do you need?

You’ll find several recipes online for DIY glutathione suppositories. Common ingredients include cocoa butter, glutathione powder, and baking soda.

ALSO READ: How Much Glutathione to Take for Skin Whitening

Conclusion: Is it Worth Taking Glutathione Suppositories for Skin Lightening Purposes?

If you’re looking for a fast, effective, safe, and inexpensive way to lighten your skin, then glutathione suppositories are a winner. Unlike many other skin whitening ingredients, glutathione not only lightens, but it’ll also benefit the rest of your health in so many different ways.



Avatar for Megan Foley

Megan has been a freelance writer and editor since 2016. In that time, she’s penned a diverse collection of articles for online publication, with a focus on skincare and beauty. From in-depth product reviews to concise marketing content, Megan is passionate about developing content that informs, entertains, and inspires.